2008 University of Southern Mississippi Schedule/Results
| Date | Opponent | Location | TV | Outcome/Time |
| 11/14/08 | Southern Miss 72, Sam Houston State 60 | Huntsville, Texas | | 12:00 p.m. |
| 11/17/08 | Southern Miss 79, Tennessee State 57 | Hattiesburg, Miss. | | 7:00 p.m.
Gametracker |
| 11/20/08 | South Alabama 66, Southern Miss 64 | Mobile, Ala. | | 7:05 p.m. |
| 11/25/08 | ULM 75, Southern Miss 57 | Monroe, La. | | 7:00 p.m. |
| 11/28/08 | Southern Miss 79, Alcorn State 47 | Hattiesburg, Miss. | | 5:00 p.m.
Gametracker |
| 12/03/08 | Southern Miss at Arkansas-Little Rock | Little Rock, Ark. | | 7:00 p.m. CT |
| 12/06/08 | William Carey at Southern Miss | Hattiesburg, Miss. | | 4:00 p.m. CT
Gametracker |
| 12/13/08 | SEMO at Southern Miss | Hattiesburg, Miss. | | 4:00 p.m. CT
Gametracker |
| 12/16/08 | Mississippi State at Southern Miss | Hattiesburg, Miss. | | 7:00 p.m. CT
Gametracker |
| 12/19/08 | Southern Miss vs. Oklahoma State
The Desert Draw at UNLV | Las Vegas, Nev. | | 3:00 p.m. CT |
| 12/20/08 | Southern Miss vs. UNLV / Cal State Northridge
The Desert Draw at UNLV | Las Vegas, Nev. | | TBA |
| 12/30/08 | Southern Miss vs. Nicholls State | Hattiesburg, Miss. | | 7:00 p.m. CT
Gametracker |
| 01/03/09 | Southern Miss at UCF | Orlando, Fla. | | 1:00 p.m. CT |
| 01/08/09 | Southern Miss at UAB | Birmingham, Ala. | | 7:00 p.m. CT |
| 01/10/09 | Southern Miss at Memphis | Memphis, Tenn. | | 2:00 p.m. CT |
| 01/18/09 | UCF at Southern Miss | Hattiesburg, Miss. | | 2:00 p.m. CT |
| 01/22/09 | Houston at Southern Miss | Hattiesburg, Miss. | | 7:00 p.m. CT |
| 01/25/09 | Southern Miss at Rice | Houston, Texas | | 2:00 p.m. CT |
| 01/29/09 | Marshall at Southern Miss | Hattiesburg, Miss. | | 7:00 p.m. CT |
| 01/31/09 | East Carolina at Southern Miss | Hattiesburg, Miss. | | 4:00 p.m. CT |
| 02/05/09 | SMU at Southern Miss | Hattiesburg, Miss. | CBS College Sports | TBA |
| 02/07/09 | Tulsa at Southern Miss | Hattiesburg, Miss. | | TBA |
| 02/13/09 | Southern Miss at East Carolina | Greenville, N.C. | | 6:00 p.m. CT |
| 02/15/09 | Southern Miss at Marshall | Huntington, W.Va. | ESPN2 | TBA |
| 02/19/09 | Southern Miss at Tulane | New Orleans, La. | | 7:00 p.m. CT |
| 02/21/09 | Southern Miss at UTEP | El Paso, Texas | | TBA |
| 02/26/09 | UAB at Southern Miss | Hattiesburg, Miss. | | 7:00 p.m. CT |
| 02/28/09 | Memphis at Southern Miss | Hattiesburg, Miss. | | 4:00 p.m. CT |
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